synapsin i (CESCA Therapeutics)
90
Structured Review
CESCA Therapeutics
synapsin i
Synapsin I, supplied by CESCA Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/synapsin+i/synapsin+i/pmc11974646-176-5-13
Average 90 stars, based on 1 article reviews
Synapsin I, supplied by CESCA Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/synapsin+i/synapsin+i/pmc11974646-176-5-13
Average 90 stars, based on 1 article reviews
synapsin i - by Bioz Stars,
2026-10
90/100 stars
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1) Product Images from "Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway"
Article Title: Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway
Journal: Neural Regeneration Research
doi: 10.4103/NRR.NRR-D-24-00628
Figure Legend Snippet: NRMS upregulates transcriptional levels of genes related to synaptic plasticity in damaged region of SCI rats. (A) The functional classification of different genes in the SCI + NRMS and SCI + SS groups by GO enrichment analysis. (B) The functional classification of different genes between the SCI + NRMS and SCI + SS groups by KEGG database. (C–F) The relative levels of Syn2 , Syp , GAP43 , and MAP2 mRNA normalized by the Sham group. The bold lines, upper boundaries, and lower boundaries represent the medians, 75 th percentiles, and 25 th percentiles, respectively. Whiskers extend 1.5 times interquartile range ( n = 4 per group). * P < 0.05, vs . Sham group; # P < 0.05, vs . SCI + SS group. GAP43: Growth-associated protein 43; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes; MAP2: microtubule-associated protein 2; NRMS: nerve root magnetic stimulation; SCI: spinal cord injury; SS: sham stimulation; Syn2: synapsin II; Syp: synaptophysin.
Techniques Used: Functional Assay
Figure Legend Snippet: NRMS alters expression of proteins associated with synaptic plasticity in the injured spinal cord of rats. (A) Representative western blots show the expression levels of PSD95, GAP43, Synapsin I and Synapsin II collected from the damaged area of spinal cord on day 22 after SCI. (B–E) The semi-quantified results of PSD95, GAP43, Synapsin I, and Synapsin II protein levels. All experiments were repeated three times. Data are expressed as mean ± SD ( n = 5 per group). ** P < 0.01, *** P < 0.001, vs. Sham group; # P < 0.05, ## P < 0.01, vs . SCI + SS group. GAP43: Growth-associated protein 43; PSD95: postsynaptic density protein-95; NRMS: nerve root magnetic stimulation; SCI: spinal cord injury; SS: sham stimulation.
Techniques Used: Expressing, Western Blot
Related Articles
Functional Assay:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Expressing:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Western Blot:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Reverse Transcription:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Software:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Phospho-proteomics:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Blocking Assay:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Incubation:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Knock-Out:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Generated:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Homologous Recombination:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Mutagenesis:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to In Vitro:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Purification:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Recombinant:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Binding Assay:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to De-Phosphorylation Assay:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Dispersion:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Double Knockout:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to Transfection:Article Title: Leucine-rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre-synaptic sites. Article Snippet: Phosphorylation of synapsin I is known to modulate its interactions with SVs and/or Article Title: Cynarin, a caffeoylquinic acid derivative in artichoke, inhibits exocytotic glutamate release from rat cortical nerve terminals (synaptosomes). Article Snippet: The purpose of this study was to evaluate the effect of cynarin, a caffeoylquinic acid derivative in artichoke, on glutamate release elicited by 4-aminopyridine (4-AP) in rat cortical nerve terminals (synaptosomes).. We observed that cynarin decreased 4-aminopyridine-elicited glutamate release, which was prevented by the removal of external free Ca2+ with ethylene glycol bis (β-aminoethyl ether)-N,N,N,N-tetraacetic acid (EGTA) or the blockade of P/Q-type calcium channels with ω-agatoxin IVA.. Molecular docking also revealed that cynarin formed a hydrogen bond with the P/Q-type Ca2+ channel, indicating a mechanism of action involving Ca2+ influx inhibition. Article Title: Xuefu Zhuyu decoction improves neurological dysfunction by increasing synapsin expression after traumatic brain injury Article Snippet: Synapsin I is a nerve terminal-specific phosphoprotein involved in synaptic Article Title: Huntingtin-associated protein-1 is a synapsin I-binding protein regulating synaptic vesicle exocytosis and synapsin I trafficking. Article Snippet: This finding may reflect a dynamic interaction between HAP1 and synapsin I, consistent with the regulatory role of synapsin I in the formation of the readily releasable pool (RRP), and its dynamic association with Article Title: MicroRNA-124 attenuates PTSD-like behaviors and reduces the level of inflammatory cytokines by downregulating the expression of TRAF6 in the hippocampus of rats following single-prolonged stress. Article Snippet: Article Title: Ganglioside GQ1b induces dopamine release through the activation of Pyk2. Article Snippet: a State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Neuroscience Center, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China b Key Laboratory of Diagnostics of Traditional Chinese Medicine, Collaborative Innovation Center of Digital Traditional Chinese Medicine, College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China c Department of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, China Article Title: An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2. Article Snippet: In an attempt to understand this change in synaptic vesicle dispersion, we next investigated the levels of synapsin I, a protein key to tethering synaptic vesicles to each other and to |